Europe warned to regulate endocrine disruptors


We’ve posted endlessly about the dangers posed by plastics and other chemicals [including those used in fracking, flame retardants, food packaging, and more] flooding the environment now demonstrated to disrupt the healthy operation of the body’s endocrine system [glands in common parlance].

Chemicals secreted by the endocrine system regulate a wide range of bodily process, everything to weight and stature to sexual characteristics.

And now the organization representing the physicians, researchers, and educators specializing in endocrine studies has called upon the European Union to strictly regulate chemicals identified as endocrine disruptors.

From the Endocrine Society:

To protect human health, Endocrine Society members called on the European Commission to adopt science-based policies for regulating endocrine-disrupting chemicals in an opinion piece published today in The Lancet Diabetes & Endocrinology.

The publication comes two days before the European Commission is expected to announce its final criteria for identifying endocrine-disrupting chemicals.

Endocrine-disrupting chemicals (EDCs) mimic, block or interfere with the body’s hormones – the chemical signals that regulate brain development, reproduction, metabolism, growth and other important biological functions. EDCs can be found in common products including food containers, plastics, cosmetics and pesticides.

More than 1,300 studies have linked EDC exposure to health problems such as infertility, diabetes, obesity, hormone-related cancers and neurological disorders, according to the Endocrine Society’s 2015 Scientific Statement. Recent studies have found that adverse health effects from EDC exposure cost the European Union more than €157 billion each year in healthcare expenses and lost productivity.

“A growing body of research has found endocrine-disrupting chemicals pose a threat not only to those who are directly exposed, but to their children, grandchildren and great-grandchildren,” said the Society’s European Union Endocrine-Disrupting Chemicals Task Force Co-Chair Jean-Pierre Bourguignon, MD, PhD, first author of the opinion piece, of the University of Liège in Liège, Belgium. “We need to protect the public and future generations with regulations that address the latest scientific findings and incorporate new information from emerging research.”

The European Commission has proposed four options for regulatory criteria identifying endocrine-disrupting chemicals. The Endocrine Society supports option 3, which would create multiple categories based on the amount of scientific evidence that a particular chemical acts as an endocrine disruptor. This option also allows for incorporating new data as more studies are published.

There’s more, after the jump. . .

In The Lancet Diabetes & Endocrinology, the authors note that other options being considered either don’t define endocrine-disrupting chemicals as clearly or include problematic criteria. Option 4 uses potency – the amount of chemical exposure needed to produce an effect – as one criterion. Since EDCs can have different and more dangerous effects when an individual is exposed to low levels, measuring potency could cause regulators to overlook endocrine disruptors that pose a true threat.

“Because of the way hormones work, even low-level exposure can disrupt the way the body grows and develops,” Bourguignon said. “Pregnant women, babies and children are particularly vulnerable, and science-based regulations are needed to protect them.”

Other authors of the opinion piece include: Rémy Slama of Inserm, CNRS and University Grenoble Alpes in Grenoble, France; Åke Bergman of the Swedish Toxicology Sciences Research Center in Södertälje, Sweden; Barbara Demeneix of Muséum National d’Histoire Naturelle in Paris, France; Richard Ivell of the University of Nottingham in Nottingham, U.K.; Andreas Kortenkamp of Brunel University London in Uxbridge, U.K.; GianCarlo Panzica of the University of Torino and Neuroscience Institute Cavalieri Ottolenghi in Orbassano, Italy; Leonardo Trasande of New York University School of Medicine in New York, NY; and R. Thomas Zoeller of the University of Massachusetts in Amherst, MA.

The comment was published [$31.50 to read — esnl] online at http://www.thelancet.com/journals/landia/article/PIIS2213-8587(16)30121-8/abstract.

Since we can’t

This Executive Summary to the Endocrine Society’s second Scientific Statement on environmental endocrine-disrupting chemicals (EDCs) provides a synthesis of the key points of the complete statement. The full Scientific Statement represents a comprehensive review of the literature on seven topics for which there is strong mechanistic, experimental, animal, and epidemiological evidence for endocrine disruption, namely: obesity and diabetes, female reproduction, male reproduction, hormone-sensitive cancers in females, prostate cancer, thyroid, and neurodevelopment and neuroendocrine systems. EDCs such as bisphenol A, phthalates, pesticides, persistent organic pollutants such as polychlorinated biphenyls, polybrominated diethyl ethers, and dioxins were emphasized because these chemicals had the greatest depth and breadth of available information. The Statement also included thorough coverage of studies of developmental exposures to EDCs, especially in the fetus and infant, because these are critical life stages during which perturbations of hormones can increase the probability of a disease or dysfunction later in life. A conclusion of the Statement is that publications over the past 5 years have led to a much fuller understanding of the endocrine principles by which EDCs act, including nonmonotonic dose-responses, low-dose effects, and developmental vulnerability. These findings will prove useful to researchers, physicians, and other healthcare providers in translating the science of endocrine disruption to improved public health.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s